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CME/CE
A 3-Year-Old Girl With Fever and a Limp
A 3-year-old girl is brought to the ED by her parents with a fever and refusal to walk secondary to pain in her right leg and back. The mother denies any history of trauma to the affected extremity. There is localized exquisite tenderness over the L1-2 region of the back, with slight induration noted in the overlying tissue. Plain radiographic films and MRI scans of the spine are obtained. What diagnosis do the findings on the MRI scan suggest?
Clinical Case, December 2008
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CME
Markers of Response to EGF Receptor Inhibitors
Dr. Jose Baselga moderates an expert panel discussion on the clinical use of predictive markers to customize treatment for patients with colorectal and lung cancers.
Commentary, December 2008
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CME/CE
48th ICAAC/46th IDSA Annual Meetings: Update on Antiretroviral Therapy
Dr. Mark A. Wainberg highlights the important presentations from the 2008 combined ICAAC/IDSA meetings (October 25-28, 2008; Washington, DC) that dealt with advances in antiretroviral therapy.
Conference Coverage, December 2008
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CME/CE
ICAAC/IDSA 2008: Antiretroviral Therapy Clinical Trials
Dr. Mark Wainberg reviews presentations from the 2008 combined ICAAC/IDSA meetings on antiretroviral therapy and Dr. John G. Bartlett answers Medscape's questions on treatment of the naive patient.
Conference Coverage, December 2008
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Assessment of Brain Natriuretic Peptide in Acute Pulmonary Embolism
Cardiac troponins and brain natriuretic peptide have been suggested as useful tools for predicting relevant outcomes in patients with pulmonary embolism.
Expert Viewpoint, December 2008
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Prescriptions for Survival
Nancy Covington, BSc, MD, President of Physicians for Global Survival, Halifax, Nova Scotia, Canada, invites us to reconnect with the physicians' movement against nuclear war.
Editorial, December 2008
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CME
Strategy for Incorporating Molecular and Cytogenetic Markers into Acute Myeloid Leukemia Therapy
Acute myeloid leukemia is a challenging disease to treat, but new molecular and cytogenetic markers can help clinicians guide patients to more effective and safe therapy. The current article reviews these markers and offers strategies for their clinical application.
Journal Article, December 2008
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CME
Complete Response of Stage IV Anal Mucosal Melanoma Expressing KIT Val560Asp to the Multikinase Inhibitor Sorafenib
Adjuvant therapy with targeted kinase inhibitors may offer new hope for patients with anal mucosal melanoma. The current case study and review highlight this exciting potential treatment.
Journal Article, December 2008
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CME/CE
A 60-Year-Old Woman With Progressive Neuropsychiatric Symptoms and Myoclonic Jerks
A 60-year-old woman presents with abnormal behavior, irritability, disorientation, forgetfulness, and unsteadiness while walking (including repeated falls). Her symptoms have evolved gradually over the past 3 months. She has also developed intermittent jerking limb movements. An electroencephalogram (EEG) is obtained. What diagnosis is suggested by the EEG?
Clinical Case, November 2008
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The End of Peer Review and Traditional Publishing as We Know It
Peter Frishauf, MS, founder of Medscape, discusses the possible end of medical journals.
Expert Viewpoint, November 2008
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CME/CE
Altered Mental Status in a Young Man Picked Up On the Street
A 33-year-old man is brought to the ED with altered mental status and agitation. On physical exam, he is extremely diaphoretic and begins convulsing. The patient’s temperature is 108.1 degrees F (42.3 degrees C), and his heart rate is 180-190 bpm, his blood pressure is 80/40 mm Hg. The patient admits to using cocaine. What is the potentially life-threatening finding on the electrocardiogram (ECG)?
Clinical Case, November 2008
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Demanding Highest Standards for New Cancer Diagnostics
New cancer diagnostics, such as a recently marketed test for ovarian cancer, should be held to the same rigorous standards as cancer therapeutics, according to Dr. Maurie Markman's latest video blog.
Expert Viewpoint, November 2008
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Prevalence and Correlates of Silent Cerebral Infarcts in the Framingham Offspring Study. Ranked "Changes Clinical Practice" From F1000.
In no other medical field are the death rates are so high, knowledge so advanced and so little is done, as in vascular disease.
Journal Article, November 2008
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CME/CE
A Cough in Kentucky
A 46-year-old man presents with a 4-day history of dry cough, fever, chills, night sweats, weight loss, shortness of breath, and easy fatigability. He recently spent time cleaning an abandoned house that had a lot of bird droppings. Chest auscultation reveals fine rales in the mid and lower zones of both lungs. A posteroanterior chest radiograph is obtained. What is the likely diagnosis?
Clinical Case, November 2008
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Failed Connections: Why Connecting Humans Is as Important as Connecting Computers
Daniel Z. Sands, MD, MPH, of Cisco and Harvard Medical School, explains why we need to learn to communicate better.
Editorial, November 2008
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Assessment of Asymptomatic Liver Fibrosis in Alcoholic Patients Using Fibroscan: Prospective Comparison With Seven Non-Invasive Laboratory Tests
Is Fibroscan effective in assessing liver fibrosis in alcoholic patients?
Journal Article, November 2008
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Systematic Review: Hepatic Fibrosis - Regression With Therapy
An impressive amount of knowledge concerning the pathogenesis and treatment of liver fibrosis has emerged over the past few years, the authors say.
Journal Article, November 2008
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Influenza: A Multipronged Approach to Protecting Our Smallest Patients
Joanne Langley, MD, MSc, Professor of Pediatrics and Community Health and Epidemiology at Dalhousie University and the IWK Health Centre, explains how to prevent children from catching influenza.
Editorial, November 2008
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Learning What Works in Healthcare
Harvey V. Fineberg, MD, President, Institute of Medicine, Washington, DC, explains why many should participate in clinical trials.
Editorial, November 2008
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American Society of Human Genetics (ASHG) 58th Annual Meeting
Read clinically focused news coverage of key developments from the meeting.
Conference Coverage, November 2008
