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The Long Road From Discovery to Clinic -- How to Cut the Bill?
Proof of activity has to be obtained early, together with some evidence of efficacy and acceptable toxicity.
Article, October 2004
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Antiangiogenesis Cocktails -- Stirred or Shaken?
Leading researchers discuss the results achieved by combinations of first- and second-generation antiangiogenic agents, and conventional or metronomic chemotherapy in cancer patients.
Journal Article, October 2004
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Targeting Cancer Cells -- More Pathways, More Inhibitors, More Trials
Researchers are looking for viable strategies to meaningfully improve on current anticancer treatments.
Journal Article, October 2004
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Lentiviral Vectors for the Central Nervous System
New approaches for the genetic treatment of CNS disorders rely on the development of suitable model systems.
Journal Article, September 2004
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Conference Report - Epigenetics -- Sound, Silence, and the Notes in Between
New findings underscore the influence exerted by epigenetic events on disease predisposition and outcomes.
Journal Article, August 2004
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Conference Report - Stem Cells and Tissue Engineering -- Dreaming Things That Never Were
More refined technologies and novel insights into how stem cells work are unveiling new possibilities for tissue repair.
Journal Article, August 2004
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Conference Report - Early Cancer Diagnosis: Beating the Odds
What can be done to improve the early diagnosis of colorectal, breast, and cervical cancers for all?
Conference Coverage, July 2004
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Telomeres, Telomerase, and Tumorigenesis -- A Review
Many tumor cells contain short and stable telomeres that confer immortality.
Journal Article, July 2004
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Conference Report - Gene Therapy -- Quality Matters
The medical community is not foreign to the notion that experimental treatments in their infancy may have to overcome significant, unforeseen hurdles.
Journal Article, July 2004
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Conference Report - Gene Therapy and Lung Cancer -- No Time to Wait
Surpassing conventional therapies, new approaches are needed to break the deadlock of poor long-term prognoses for lung cancer patients.
Journal Article, July 2004
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Transfusion of RhD-Incompatible Blood Components in RhD-Negative Blood Marrow Transplant Recipients
Rh-negative patients with hematologic cancers are at low risk of developing RhD antibodies.
Journal Article, July 2004
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Conference Report - Novel Therapies for Systemic Lupus Erythematosus?
Are we moving toward better and more selective treatments for SLE?
Journal Article, July 2004
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Conference Report - Lupus Nephritis: Diagnosis, Therapy, and Outcomes
An analysis of the latest epidemiologic data, the new consensus classification, some of the current therapeutic options, and outcome-correlated prognostic factors.
Journal Article, July 2004
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Underreporting of Minor Transfusion Reactions in Cancer Patients
A problem or a routine medical practice?
Journal Article, May 2004
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Conference Report - At the Forefront of Cancer Research: Preclinical Data
Have small-molecule inhibitors of intracellular protein-protein interactions indeed come of age?
Journal Article, May 2004
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Conference Report - At the Forefront of Cancer Research: Clinical Results
New pathways and new management strategies have to be explored to achieve better control of renal cell carcinoma.
Journal Article, May 2004
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Conference Report - Cancer Research 2004 -- Top of the Class
Novel imaging technologies for mammolymphangiography, optimization of cellular gene-delivery systems, and new insights in the biology and treatment of breast and prostate cancers.
Journal Article, April 2004
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Conference Report - Genomics: The Promise of SNPs and Bats
Homo sapiens: a unique species of unique individuals.
Journal Article, April 2004
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Conference Report - Structural Genomics: Parsing the Architecture of Proteins
It would take an almost "infinite" time to solve the structures of all proteins present on Earth, if we keep going at the current speed.
Journal Article, April 2004
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Conference Report - Engineering Proteins: Interferon, Diphtheria Toxin, and Growth Hormone
An outline of the steps involved in the design/production of recombinant biologics, and the unexpected findings that may arise along the way
Journal Article, April 2004
