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Genetics of Melanoma Predisposition
Our understanding of melanoma at the molecular level has blossomed with the advent of genomic technologies. In this review, the authors consider some of the clinical implications of these genetic findings for both diagnostics and therapeutics.
Journal Article, August 20, 2008
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False-Positive Oral Fluid Rapid HIV Tests -- New York City, 2005-2008
NYC Department of Health and Mental Hygiene STD walk-in clinics introduced oral fluid rapid HIV testing in 2005. The results of this testing were monitored. What was observed? What actions were taken?
Journal Article, August 20, 2008
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Public Health Consequences of a False-Positive Laboratory Test Result for Brucella -- Florida, Georgia, and Michigan, 2005
Human brucellosis, an uncommon disease in the US, was identified in a Florida woman in January 2005. What were the results of the case history, laboratory findings, and public health investigations?
Journal Article, August 20, 2008
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CME
A Change in Upper Extremity Examination
A 45-year-old woman suffers several complications during treatment for right pleural effusion. A change in her right hand is noticed; it is blistered, extremely swollen, and tense. The radial and ulnar pulses are not palpable. What is the underlying etiology?
Clinical Case, August 20, 2008
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Sugar and Fat - That's Where it's at: Metabolic Changes in Tumors
Sugar and fat have long been known to increase tumor metabolism. This article provides an in depth look at these metabolic processes, identifying potential therapeutic targets.
Journal Article, August 19, 2008
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Progressive Supranuclear Palsy and Corticobasal Degeneration: Similarities and Differences
This article discusses the similarities and differences between these disorders in clinical manifestations, neuroimaging and neuropathology and provides a perspective on possible future developments.
Journal Article, August 19, 2008
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The Origins of Bladder Cancer
Alterations of the forerunner gene status provide a novel opportunity to screen individuals at risk for the earliest stage of bladder pre-neoplasia.
Journal Article, August 18, 2008
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Optimization of the Use of B-Type Natriuretic Peptide Levels for Risk Stratification at Discharge in Elderly Patients With Decompensated Heart Failure
BNP risk stratification for elderly heart failure patients: Who, what, where, and when. Find out more about monitoring BNP changes over time.
Journal Article, August 18, 2008
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Helicobacter pylori Invades the Gastric Mucosa and Translocates to the Gastric Lymph Nodes
The bacteria captured by macrophages, whether remaining alive or not, may contribute to the induction and development of H. pylori-induced chronic gastritis.
Journal Article, August 15, 2008
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Does Your Patient's Race Affect the Care That You Deliver?
Carolyn Clancy, MD, Director, Agency for Healthcare Research and Quality, Rockville, Maryland, describes how to eliminate racial disparities in your practice.
Editorial, August 15, 2008
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Healing Iraq One Book at a Time: Medical Texts and Periodical Donations to Iraqi Healthcare Professionals
Do you have books, journals, video, or patient education materials you can donate to healthcare professionals in need? Rehabilitation materials are needed, as well as general books and journals.
Journal Article, August 14, 2008
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Pharmacologic Stress Testing: A New Selective Vasodilator
Regadenoson--Will it allow stress testing in COPD patients? A commentary on the results from Harrison's Online.
Journal Article, August 14, 2008
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The Cancer Stem cell Hypothesis: In Search of Definitions, Markers, and Relevance
Rigorous study design and critical data interpretation have to be employed to test the scientific and clinical relevance of the cancer stem cell hypothesis.
Journal Article, August 14, 2008
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CME
Strategies for Discovering Novel Cancer Biomarkers Through Utilization of Emerging Technologies
Cancer biomarkers are used to help diagnose and manage patients, and new technologies promise to increase the application of cancer biomarkers in the clinical setting. The current review highlights advances in the field of cancer biomarkers.
Journal Article, August 14, 2008
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A Day Too Long: Rethinking Physician Work Hours
Resident and fellow physicians now work shorter shifts as mandated by American training programs. But an attending physician realized that there was an exception to this rule. Read his story.
Journal Article, August 13, 2008
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Quantitative Expression Profiling of Highly Degraded RNA from Formalin-fixed, Paraffin-embedded Breast Tumor Biopsies by Oligonucleotide Microarrays
A new method proved itself sensitive, reproducible and accurate, when compared to results obtained by microarray analysis of RNA extracted from snap-frozen tissue of the same tumor.
Journal Article, August 13, 2008
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CME
A 34-Year-Old Pregnant Woman with Acute Severe Abdominal Pain
A 34-year-old woman presents to the ED with a 2-hour history of severe abdominal pain, 2 episodes of light-headedness, and loss of consciousness. She is about 6 weeks pregnant; the pain started suddenly the morning of presentation. What is the diagnosis?
Clinical Case, August 13, 2008
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Routine Reporting of Estimated Glomerular Filtration Rate: Not Ready for Prime Time
The authors of this Viewpoint argue that mandatory reporting of estimated glomerular filtration rate leads to misdiagnosis of chronic kidney disease and to unnecessary referrals.
Journal Article, August 12, 2008
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Human Adenovirus Type 36 Enhances Glucose Uptake in Diabetic and Nondiabetic Human Skeletal Muscle Cells Independent of Insulin Signaling
These findings may provide impetus to exploit the role of Ad - 36 proteins as novel therapeutic targets for improving glucose handling.
Journal Article, August 12, 2008
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Retooling for an Aging America
Harvey V. Fineberg, MD, President, Institute of Medicine, Washington, DC, discusses the impact of the "baby boomer" generation on medicine.
Expert Viewpoint, August 11, 2008
